Methods and compositions for improved human red blood cell survival in genetically modified immunodeficient non-human animals

摘要

Genetically modified immune RTI ID = 0.0 immune / RTI cells, including genetic modifications that render the non-human animal deficient in macrophage and / or macrophage anti-human erythropoietic activity so that its genome is extended into non- Deficient non-human animals are provided according to aspects of the present invention. Methods of assaying the effect of putative therapeutic agents in such genetically modified immunodeficient non-human animals are provided by the present invention.