TSG56 RNA Modified RNA aptamer specifically binding to surface protein TSG56 of the orientia tsutsugamushi Gilliam strain

摘要

The present invention relates to a modified RNA aptamer specifically binding to the surface protein TSG56 of Orientia Tsutsugamushi, a causal bacterium of Tsutsugamushi disease, an acute febrile disease in autumn. According to the present invention, provided is a single-stranded nucleic acid aptamer which binds specifically to the surface protein TSG56 of Orientia Tsutsugamushi and includes at least one base sequence from base sequences of SEQ ID NO: 1 or SEQ ID NO: 2. In addition, as the single-stranded nucleic acid aptamer has a base sequence of SEQ ID NO: 1 or 2 in which the 2′-hydroxyl group in uracil (U) and cytosine (C) is substituted with a fluoro group among bases, the modified RNA aptamer useful in detection of Orientia Tsutsugamushi, the bacteria causing Tsutsugamushi disease can be provided.