HERV-E Reactive T Cell Receptors and Methods of Use Thereof

摘要

The present invention provides T cell receptors (TCRs) capable of binding antigens expressed in renal cell carcinoma cells. In some embodiments, the TCR comprises an alpha chain (SEQ ID NO: 2) and a beta chain (SEQ ID NO: 3). The present invention also provides a vector comprising a nucleic acid encoding said TCR alpha and / or beta chain. The invention also provides modified T cells that express said TCR. In some embodiments, the modified T cell is produced by transducing T cells with a vector comprising a nucleic acid encoding a TCR a chain and a TCR beta chain. In addition, the present invention provides a method for producing a T cell population, comprising: obtaining a population of T cells, transducing said T cell population with a vector comprising a nucleic acid encoding a TCR a chain and a TCR beta chain, Comprising administering to the subject a composition comprising a population of T cells that have been treated with the RCC.