Methods for producing nor-opioids and n-opioid benzylisoquinoline alkaloids

摘要

Methods for demethylating an opioid with a nor-opioid are provided. The method comprises contacting an opioid with at least one enzyme. Contacting the opioid with the at least one enzyme converts the opioid to a nor-opioid. A method of converting a nor-opioid to a nal-opioid is provided. The method comprises contacting a nor-opioid with at least one enzyme. Contacting said nor-opioid with said at least one enzyme converts said nor-opioid to a nal-opioid.