Methods for molecular dynamics assessment and screening methods

摘要

A protein degradation inducing tag which has affinity for a protease and which is a molecule that does not inhibit degradation of the protein by a protease and a protein degradation inducing molecule which is a conjugate of a specific protein affinity molecule having affinity for a specific protein, Or non-human animal, and inducing the degradation of the specific protein in vivo in the human or non-human animal; And a step of evaluating the molecular dynamics of the specific protein affinity molecule or the proteolysis-inducing molecule by detecting the degradation of the specific protein in a sample that is at least a part of the human or non-human animal. to provide.