Phosphine oxide alkyl amide substituted heteroaryl compounds as modulators of IL-12, IL-23 and / or IFN alpha reactions

摘要

Compounds having the formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, wherein all substituents are as defined herein, act on Tyk-2 to cause signal transduction inhibition, thereby causing IL-12, IL-23 and / or Or to modulate IFNα.