Aerial Oxidation of 2,2-Dibromo-1-Aryl and Heteroaryl Ethanones: A Facile Synthesis of Aryl and Heteroaryl alpha-Keto Amides

摘要

The aerial oxidation of various 2,2-dibromo-1-aryl and heteroaryl ethanones to alpha-keto amides in the presence of air or oxygen and secondary amines are described. The reaction provides alpha-keto amides in moderate to good yields. The versatility of the reaction was established by synthesizing a series of alpha-keto amides by the reaction of dibromoethanones derived from aryl and heteroaryl ketones with cyclic and acyclic aliphatic secondary amines.