PSD-95 COMBINATION THERAPY WITH PSD-95 INHIBITOR FOR ISCHEMIA

摘要

The present invention provides a combination treatment for ischemic diseases, such as stroke, that affect or otherwise affect the CNS. The treatment includes administering a PSD-95 inhibitor and performing reperfusion therapy (eg, by administering tPA). Administration of a PSD-95 inhibitor in combination with reperfusion therapy increases the efficacy of reperfusion therapy and / or slows the decline in efficacy of reperfusion therapy over time after the onset of ischemia, thereby providing a window into which reperfusion therapy can be provided. Extend.