T Composition for modulating immunity comprising myeloid-derived suppressor cells and regulatory T cell

摘要

The present invention relates to a pharmaceutical composition for immunomodulation comprising myeloid-derived suppressor cells (MDSC) and regulatory T cell (Treg) as active ingredients; and various applications thereof. It has been confirmed that the composition of the present invention increases Foxp3+Treg cells and IL-10 derived CD1d+CD5+ Breg cells, and suppresses IL-17+CD4+T cells. Therefore, it has been confirmed that a significant immune-modulating activity exists in the combined treatment of MDSC and Treg since combined treatment of MDSC and Treg exhibits a synergistic effect compared to single treatment of MDSC or Treg. Further, according to the present invention, the composition can be useful in related pharmaceutical and food industries as it has been confirmed that the composition has a significant treatment effect in Sjogren syndrome and graft-versus-host disease due to the synergistic effect.