HMGB1 A method for pathogenesis prediction to kawasaki disease using the HMGB1 genes SNP

摘要

The present invention relates to a method for predicting symptoms of Kawasaki disease using polymorphism of an HMGB1 gene. Kawasaki disease is an acute heat rash lesion mainly appearing in infants and young children less than 5 years old, and may cause a coronary artery lesion when treatment involving proper uses of intra-venous immunoglobulin (IVIG) is not received. However, there are many cases that IVIG resistance is generated from a Kawasaki disease patient, such that difficulty follows in the treatment. According to the present invention, the method for predicting symptoms of Kawasaki disease using polymorphism of an HMGB1 gene characterizes correlation between an HMGB1 gene and the symptoms of Kawasaki disease to predict possibility of causing the coronary artery lesion or the IVIG resistance in a Kawasaki disease patient, thereby being expected to be largely used in a medical field.