- Composition for preventing or treating ischemic cardiac diseases comprising inhibiting agent for synthesis or secretion of AGE-albumin of mononuclear phagocyte as active ingredient

摘要

The present invention relates to a pharmaceutical composition for the prevention or treatment of ischemic heart disease, which comprises, as an active ingredient, an inhibitor which inhibits the synthesis or secretion of AGE-albumin of mononuclear cells that induce cell death of myocardial cells at the onset of ischemic heart disease, To a screening method. The pharmaceutical composition for the prevention or treatment of ischemic heart disease of the present invention can inhibit or reduce the cell death induced by AGE-albumin by including the synthesis or secretion inhibitor of AGE-albumin of mononuclear cells as an active ingredient, And may be widely used for the prevention or treatment of various ischemic heart diseases.