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17- - 17-Hydroxyprogesterone ester-containing oral compositions and related methods
17- - 17-Hydroxyprogesterone ester-containing oral compositions and related methods
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机译:含17--17-羟基孕酮的口服组合物和相关方法
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摘要
The present invention provides a bioavailable oral dosage form containing esters of 17-hydroxyprogesterone and related methods. The oral dosage form may be formulated for pregnancy support and may include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. In another embodiment, a pharmaceutically acceptable oral dosage form for gestational support is provided. Pharmaceutically acceptable oral dosage forms may comprise a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. Oral dosage forms were prepared by dissolving the ester of 17-hydroxyprogesterone after 60 minutes at 37 占 폚 measured at 50 RPM in 900 mL of deionized water with 0.5 (w / v) sodium lauryl sulfate using a USP Type -II dissolver More than 20 wt% of the dose of the drug or, alternatively, more than 20 wt% more than 60 minutes after the oral dosage form, which is administered without carrier.
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