首页> 外国专利> Development of affinity ligand for antibody purification with high binding capacity and mild elution condition and use thereof

Development of affinity ligand for antibody purification with high binding capacity and mild elution condition and use thereof

机译:具有高结合能力和温和洗脱条件的抗体纯化亲和配体的开发及其应用

摘要

The peptide of the present invention can be usefully used for IgG fixing or purification since the amino acid at a specific position in the amino acid sequence is substituted with another amino acid to control the binding force to IgG. In addition, the peptide having improved binding ability to IgG of the present invention has excellent binding ability to IgG, and elutes IgG under mild pH conditions, and has excellent refining ability even after repeated use for a plurality of times, thereby being usefully used in an IgG purification column .
机译:由于氨基酸序列中特定位置的氨基酸被另一种氨基酸取代以控制与IgG的结合力,因此本发明的肽可用于IgG的固定或纯化。另外,本发明的与IgG的结合能力提高的肽与IgG的结合能力优异,在温和的pH条件下洗脱IgG,即使多次重复使用也具有优异的精制能力,因此可用于IgG纯化柱。

著录项

  • 公开/公告号KR101966301B1

    专利类型

  • 公开/公告日2019-04-08

    原文格式PDF

  • 申请/专利权人 앱티스 주식회사;

    申请/专利号KR20170065171

  • 发明设计人 정상전;최원우;강효진;김주환;

    申请日2017-05-26

  • 分类号C07K7/08;C07K1/14;C07K16/06;

  • 国家 KR

  • 入库时间 2022-08-21 11:48:51

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