Method for evaluating therapeutic effects of sepsis

摘要

The present invention relates to a method of measuring the effect of an agent for treating sepsis. More specifically, the 2-hit model allows sepsis to occur in medium-sized animals, making it more difficult to induce disease and controlling the pattern of sepsis, making it easier to measure the effectiveness of the sepsis treatment and to facilitate verification. It is about how to. According to the present invention as described above, by causing sepsis in the medium-sized animals to increase the disease induction and control the aspect of sepsis, there is an effect that can be similar to the effect in humans the effect of the candidate drug for sepsis treatment . In addition, antemortem exams such as continuous blood collection and biopsy are possible. In addition, since there is a long-term damage scoring system for quantitative evaluation of disease, such as the human Apache score (APACHE score), long-term damage can be quantitatively evaluated after inducing a disease model.