- Betaglucan-peptide complexes preparation method thereof and pharmaceutical composition for use in preventing or treating inflammatory diseases containing the same as an active ingredient

摘要

The present invention relates to a beta-glucan-peptide complex, a process for its preparation, and a pharmaceutical composition for the prophylaxis or treatment of inflammatory diseases containing it as an active ingredient. More particularly, the SPG-c-Src-SH3 peptide complex is prepared by covalently binding SH3 peptide derived from c-Src with Schizophyllan (SPG), which is a beta-1,3-glucan, And to a pharmaceutical composition for the prophylaxis or treatment of inflammatory diseases such as sepsis and colitis. The betaglucan-peptide complex according to the present invention targets p47phox and significantly inhibits the production of reactive oxygen species (ROS) and inflammatory cytokines, and thus is useful as a pharmaceutical for the prevention or treatment of a fatal inflammatory disease associated with ROS such as sepsis and colitis May be useful as a composition. On the other hand, it can be useful for the development of new peptide-based drugs targeting p47phox.