Composition for Preventing or Treating Brain Tumor Comprising Calcium-Activated Chloride Channel Inhibitors

摘要

The present invention relates to a pharmaceutical composition for preventing or treating brain tumors containing a chloride channel blocker as an active ingredient, and more particularly, to a method for preparing a derivative of T16Ainh-A01, will be. The structurally modified aminophenyl thiazole derivative of the calcium-dependent chloride channel blocker T16Ainh-A01 according to the present invention has an improved anticancer activity and BBB permeability against glioblastomas compared with T16Ainh-A01 before modification, The cancer showing excellent anticancer activity can be used as an agent for preventing or treating improved brain tumor.