Magnetic nanostructure for detecting and isolating circulating tumor cells comprising antibody- and magnetic nanoparticle-conjugated conductive polymer

摘要

The present invention relates to a magnetic nanostructure for detecting and recovering blood cancer cells comprising a conductive polymer to which an antibody and magnetic nanoparticles are bound. The magnetic nanostructure according to the present invention can be used for blood cancer cells It is possible to efficiently detect various kinds of blood cancer cells and to monitor cancer blood cells in the blood through visual detection through colorimetric detection and to detect a cancer cell in blood with high intensity by a strong magnetic field generated by mounting a large amount of magnetic nanoparticles Can capture. In addition, in the detection, separation and recovery of blood cancer cells present in very small quantities, due to the long structure of nanowires and the use of various antibodies, it is possible to increase the contact with cancer cells and not only form a firm bond, By promoting multiple interactions with cancer cells, they exhibit significantly increased detection and isolation effects over the prior art. Therefore, the magnetic nanostructure according to the present invention is expected to be used for early diagnosis and treatment of cancer, as well as DNA mutation diagnosis service by extracting DNA from blood cancer cells.