Endosomal escape motif enabling antibody to escape from endosomes and uses thereof

摘要

The present invention relates to an endosomal escape structural motif and its use for imparting endosomal escape ability to an antibody. More particularly, the present invention relates to an endosomal escape structural motif for imparting endosomal escape ability to a cytosol-penetrating antibody (Cytotransmab), a light chain variable region comprising the endosomal escape structural motif and / A pharmaceutical composition for the treatment, prophylaxis or diagnosis of a cancer comprising the antibody, and a method for producing an antibody having enhanced endosomal elimination ability.