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Anti-aging cosmetic composition containing novel heptapeptide monomer and dimer that promotes collagen synthesis

机译:含有新型七肽单体和促进胶原蛋白合成的二聚体的抗衰老化妆品组合物

摘要

The present invention relates to a cosmetic composition for preventing or improving skin aging containing a novel heptapeptide monomer and dimer represented by the following formulas 1 to 4 as an active ingredient, and more particularly, a novel heptapeptide monomer and dimer. It inhibits the expression of MMP-1, an important enzyme that causes skin aging, as an active ingredient, inhibits skin collagen degradation and increases the expression of procollagen, thereby preventing and improving skin aging. It relates to a cosmetic composition for. In particular, the heptapeptide monomers and dimers for preventing and improving skin aging can be added to various cosmetic compositions such as skins, lotions, creams, foundations, essences, gels, packs, foam cleansing or soap forms, and have no skin irritation. Skin stability is also excellent. [Formula 1] [Cys-Gly-Pro-Gln-X-Pro-Gln] (2) Gly-X-Gln-Gly-Pro-Gln-Cys (3) [Cys-Gly-Pro-Gln-X-Pro-Gln] 2 [Chemical Formula 4] Gly-X-Gln-Gly-Pro-Gln-Cys 2 (In the formula 1 to 4, X is glutamic acid, aspartic acid, histidine, phenylalanine, alanine, cysteine, glycine, glutamine, asparagine, arginine, leucine, methionine, isoleucine, serine, tyrosine, threonine, lysine, tryptophan Selected from, proline and valine, and [] 2 may represent a dimer of a thiol group (-SH), which is a cysteine residue, in a reduced form (-SS-).)
机译:本发明涉及用于预防或改善皮肤衰老的化妆品组合物,其包含由下式1-4表示的新型七肽单体和二聚体作为活性成分,并且更具体地,涉及新型七肽单体和二聚体。它抑制MMP-1的表达,MMP-1是引起皮肤衰老的重要酶,是一种有效成分,可抑制皮肤胶原蛋白的降解并增加胶原蛋白的表达,从而预防和改善皮肤衰老。本发明涉及一种化妆品组合物。特别地,可以将用于预防和改善皮肤老化的七肽单体和二聚体添加到各种化妆品组合物中,例如皮肤,洗剂,霜剂,粉底,粉底液,香精,凝胶,包装,泡沫清洁剂或肥皂形式,并且不刺激皮肤。皮肤稳定性也极好。 [公式1] [Cys-Gly-Pro-Gln-X-Pro-Gln](2)Gly-X-Gln-Gly-Pro-Gln-Cys(3)[Cys-Gly-Pro-Gln-X-Pro -Gln] 2 [化学式4] Gly-X-Gln-Gly-Pro-Gln-Cys 2 (在式1-4中,X是谷氨酸,天冬氨酸,组氨酸,苯丙氨酸,丙氨酸,半胱氨酸,甘氨酸,谷氨酰胺,天冬酰胺,精氨酸,亮氨酸,蛋氨酸,异亮氨酸,丝氨酸,酪氨酸,苏氨酸,赖氨酸,色氨酸,选自脯氨酸和缬氨酸,以及[] 2 可以还原形式(-SS-)代表半胱氨酸残基的巯基(-SH)的二聚体。)

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