The present invention relates to a composition for preventing, ameliorating or treating cancer, including the auditory extract or a fraction thereof, and the TRAIL protein. A pharmaceutical composition for preventing or treating cancer according to the present invention, a pharmaceutical composition for enhancing anticancer effect of TRAIL, a method for enhancing cancer cell death, a method for preventing or treating cancer and a dietary supplement for preventing or improving cancer can overcome TRAIL resistance By including the auditory extract or fractions thereof, it can be usefully used for the prevention or treatment of cancers resistant to TRAIL.
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