Transgenic mouse capable of controlling site-specific modification of target protein temporally and spatially method and uses thereof

摘要

The present invention is a mouse (Mus the location-specific modifications of the desired protein to be time and space controlled by musclus ), a method for producing the same, and a use thereof, and more particularly, to a transgenic mouse in which expression of a target protein to which a modification of a specific position is attached upon spatiotemporal injection into an unnatural amino acid is controlled. Since a mouse capable of temporally and temporally controlling the position-specific modification of the target protein according to the present invention can control the expression of the target protein to which the position-specific modification is attached according to the injection time and / or the injection position of the non-natural amino acid, It is useful for in vivo function research and new drug development.