Vaccine composition for preventing or treating porcine pleuropneumonia

摘要

The present invention relates to a fusion protein comprising a fragment of the pleural pneumococcal ApxIA protein and a fragment of the pleural pneumococcal ApxIIA protein, wherein a part of the N terminal of ApxIA, a structural protein of ApxI, among the components A, B, C, and D of the toxin ApxI The vaccine using the fusion protein L fused with NA (1 ~ 380 amino acid), which is a partial protein of A, and F # 5 (439 ~ 801 amino acid), a partial protein of ApxIIA, a structural protein of ApxII toxin, It can be used as a vaccine against the two serotypes of pleural pneumococcus by confirming that it has a protective effect against serotype 1 of the pleural pneumococcus having a combination, as well as serotype 2 of the pleural pneumococcal having a combination of ApxII and ApxIII toxin. Do.