EGF MODIFIED EGF PROTEIN WITH IMPROVED TRANSDERMAL DELIVERY COSMETIC COMPOSITION FOR IMPROVEMENT OF SKIN CONDITION AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING SKIN DISEASES COMPRISING THE SAME

摘要

The present invention relates to a modified EGF protein with improved transdermal delivery rate, and a cosmetic composition for improving skin condition comprising the same as an active ingredient. The present invention also relates to a pharmaceutical composition for preventing or treating skin diseases comprising the modified EGF protein as an active ingredient. The modified EGF protein according to the present invention can increase cell permeability and half-life by binding to cell membranes and efficiently delivering EGF protein into cells. In addition, the modified EGF protein is maintained in an intact form even under severe conditions to improve long-term stability, it is very effective in applying to cosmetic compositions and pharmaceutical compositions having a short shelf life, difficult storage and distribution due to protein denaturation. Therefore, the present invention can be utilized as a new cosmetic composition or pharmaceutical composition improved cell permeability, in vivo persistence and stability compared to the existing EGF.