Composition for inhibiting a growth of lung cancer stem cells comprising ciclesonide

摘要

The present invention comprises a ciclesonide or a pharmaceutically salt thereof as an active ingredient, a composition for inhibiting cancer stem cell growth, inhibiting metastasis of cancer comprising the composition, or a pharmaceutical composition for treating or preventing cancer, a food composition Etc. The ciclesonide of the present invention inhibits the growth of breast cancer and lung cancer cells, and inhibits the formation of breast cancer and lung cancer stem cells. In addition, it inhibited the expression of self-renewing genes such as Nanog, C-myc, Oct4, Sox2, Snail and CD44, which are known to be characteristically expressed in breast and lung cancer stem cells. Inhibition of the production of IL-6 and IL-8, which are known to be involved in the formation of tumor pairs, was confirmed to inhibit the STAT3 signaling pathway. Accordingly, the compound inhibits the growth of cancer stem cells, such as breast cancer and lung cancer, and the growth of these cancers, and can be used for the treatment of cancers such as breast cancer and lung cancer.