treatment of cancer by u0445u0438u043cu0435u0440u043du043eu0433u043e u0430u043du0442u0438u0433u0435u043du043du043eu0433u043e u0440u0435u0446u0435u043fu0442u043eu0440u0430 to CD33

摘要

The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.