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MEANS OWNED WITH REALIZED IMPACT ON THE ORGANISM

机译:对有机体有切实影响的手段

摘要

FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to preparations of peptidic origin, having nootropic action. Disclosed agent is an oral dosage form and contains cyclo (prolyl-alanine) in amount of 4–10 wt. % immobilized on a sorbent which is D-mannitol and excipients. Composition enables to obtain a granular or tablet dosage form when adding auxiliary substances. Implementation of the invention enables to obtain an agent providing a bioavailability coefficient of cyclo (prolyl-alanine) with intragastric introduction to 0.88±10.05, that is approximately 90 % of the preparation introduced peros falls into the bloodstream.EFFECT: with oral administration of the declared agent, evident protoprotective activity is observed, preservation of the memorable trace in healthy individuals and individuals with ischemic cerebral involvement is increased, which makes the preparation promising for treating cognitive brain injuries and similar diseases.5 cl, 3 tbl, 9 ex
机译:技术领域本发明涉及药物,即具有促智作用的肽来源的制剂。公开的剂型是口服剂型,含有4-10 wt%的环(脯氨酰丙氨酸)。 %固定在D-甘露醇和赋形剂的吸附剂上。当添加辅助物质时,组合物能够获得粒状或片剂剂型。本发明的实施使得能够获得提供环内(脯氨酰-丙氨酸)的生物利用度系数的试剂,其中胃内引入的该利用率为0.88±10.05,大约是引入的Peros制剂的90%落入血流中。声明的药物,观察到明显的原代保护活性,在健康个体和缺血性脑受累个体中值得纪念的痕迹的保留增加,这使得该制剂有望用于治疗认知性脑损伤和类似疾病。5cl,3 tbl,9 ex

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