USE OF N-(6,8,8-TRIMETHYL-8,9-DIHYDROFURO3,2-HQUINOLIN-5-YL)ACETAMIDE AS AN AGENT FOR PHOTOTHERAPY OF PSORIASIS AND PSORIATIC ARTHRITIS

摘要

FIELD: medicine; pharmaceuticals.;SUBSTANCE: invention refers to medical chemistry, pharmaceutics and dermatology and can be used for phototherapy of psoriasis and psoriatic arthritis. Disclosed is the use of N-(6,8,8-trimethyl-8,9-dihydrofuro[3,2-h]quinoline-5-yl)acetamide as a skin-acting photosensitizer for treating psoriasis and psoriatic arthritis by PUVA therapy.;EFFECT: use of N-(6,8,8-trimethyl-8,9-dihydrofuro[3,2-h]quinolin-5-yl)acetamide in combination with irradiation with long-wave ultraviolet light reduced skin hyperkeratosis and lymphocyte content of Th17-type and production of IL-17 and IL-23 lymphokines (key biological markers of psoriatic skin lesions) with efficacy not lower than authorized ammifurin preparation with low toxicity in intragastric and ocular administration; in contrast to ammifurin it is effective both at subminimal, and at minimum phototoxic doses.;3 cl, 4 dwg, 8 tbl