ANTIFUNGAL SEMI-SYNTHETIC POLYENE ANTIBIOTIC, WATER-SOLUBLE SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS BASED THEREON

摘要

FIELD: chemistry.;SUBSTANCE: present invention relates to salts of acetate, L-glutamate, citrate or fumarate of amphotericin B N-(2-aminoethyl)amide of formula I ; , ;which can be used in medicine. Pharmaceutical compositions are effective against diseases caused by C. albicans, C. parapsilosis, C. krusei, C. tropicalis, C. glabrata, M. canis, T. Rubrum, Aspergillus.;EFFECT: novel antifungal compounds with reduced toxicity and improved stability, pharmaceutical compositions based thereon for treating fungal infections.;10 cl, 5 dwg, 2 tbl, 8 ex