PHARMACEUTICAL COMPOSITIONS FOR TREATING DISEASES MEDIATED BY A TRANSMEMBRANE REGULATOR OF CYSTIC FIBROSIS (CFTR)

摘要

FIELD: medicine; pharmaceuticals.;SUBSTANCE: disclosed is a pharmaceutical composition comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-di-tert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, reducing the severity or symptomatic treatment of CFTR mediated diseases, such as cystic fibrosis, methods of production, methods of administration and kit thereof.;EFFECT: presented are pharmaceutical compositions for treating diseases mediated by a transmembrane regulator of cystic fibrosis CFTR.;43 cl, 7 tbl, 12 dwg