METHOD FOR PREDICTION OF RISK OF OBESITY IN CHILDHOOD

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to pediatrics, and can be used for prediction of risk of developing obesity in childhood. Risk factors are accessed and calculated by formula. From the past medical history, such risk factors as tainted heredity by arterial hypertension, tainted heredity of obesity, tainted heredity by metabolic disorders – obesity and diabetes mellitus in individuals of I, II degree of relationship, pathological course of pregnancy – preeclampsia, incomplete family, low physical activity, carriage of isoform of E4 gene of APOE, carriage of G-allele of PPARG gene. Duration of exclusive breastfeeding is elucidated. Risk of developing obesity is determined by formula D=1.029*X1+1.29*X2+0.855*X3+0.74*X4+0.094*X5+1.234*X6+0.834*X7+0.125*X8+(-0.081)*X9-4.04, where X₁ – tainted heredity of arterial hypertension: no – 0, yes – 1, X₂ – tainted heredity in obesity: no – 0, yes – 1, X₃ – tainted heredity by metabolic disorders – obesity, type 2 diabetes mellitus – for I, II degree of relationship: no – 0, yes – 1, X₄ – pregnancy pathology – preeclampsia: no – 0, yes – 1, X₅ – incomplete family: no – 0, yes – 1, X₆ – low physical activity of the child: no – 0, yes – 1, X₇ – isoform of E4 gene of APOE: no – 0, yes – 1, X₈ – G-allele of PPARG gene – rs1801282: no – 0, yes – 1, X₉ – duration in months exclusively breastfeeding without use of adapted and unadaptated mixtures. If D0, a high risk of developing obesity is predicted with 97 % probability. If D0, a low risk is predicted with 98 % probability.;EFFECT: method enables distinguishing a group of high risk of developing obesity in children as a result of integrated risk assessment.;1 cl, 10 tbl, 3 ex