5-ETHOXY-2-(ETHYLSULFANYL)-1H-BENZIMIDAZOL-3-YUM (2E)-3-CARBOXYPROP-2-ENOATE, A METHOD FOR PRODUCTION THEREOF AND AN ACTOPROTECTOR AGENT BASED THEREON

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to a novel compound – 5-ethoxy-2-(ethylsulfanyl)-1H-benzimidazol-3-yum(2E)-3-carboxyprop-2-enoate (C₁₁H₁₄N₂OS⋅C₄H₄O₄) of formula I. Invention also relates to a method of producing compound of formula I; .;Method involves mixing mixture of 5-ethoxy-1H-benzimidazole-2-thiol, diethyl sulphate and a base in molar ratio of 1:1.1:1.1 in an aqueous medium at room temperature. Formed alkylation product – 5-ethoxy-2-(ethylsulfanyl)-1H-benzimidazole – in the form of a precipitate is separated and treated with fumaric acid in molar ratio of 1:1 in acetone medium at 50 °C with further extraction of end product. Base is usually NaOH. Acetone is distilled to extract the target product.;EFFECT: compound has antihypoxic and stress protective action and can be used as an active ingredient for the actoprotector agent.;5 cl, 3 ex