METHOD FOR ASSESSMENT OF EFFICIENCY OF ALLERGEN-SPECIFIC IMMUNOTHERAPY IN ALLERGIC RHINITIS

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely immunology and allergology, and can be used for assessment of efficiency of allergen-specific immunotherapy (ASIT) with allergic rhinitis. For this purpose, peripheral blood before and after ASIT determining the number of regulatory T-cells, the FOXP3 molecule isoform expression level by flow cytometry, expression level of mRNA of transcription factors GATA3, TBX21 and RORC by real-time polymerase chain reaction. If the functional activity of regulatory T-cells is enhanced by increasing the number of cells expressing exon 2 FOXP3 molecule, reducing the GATA3 / TBX21 ratio and reducing the RORC mRNA expression, the positive effect of ASIT before end of season of palination.;EFFECT: invention enables detecting a group of patients based on the evaluation of functional activity of the peripheral blood plasma, in which the conducted ASIT is accompanied by a high therapeutic effect, has a long-term character and persists at the end of the season of palination.;1 cl, 2 dwg, 3 tbl, 2 ex