METHOD FOR PREDICTING THE EFFECTIVENESS OF AN ANTIPLATELET THERAPY WITH THE PREPARATION 'CLOPIDOGRELUM'

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to clinical pharmacology, and concerns predicting the effectiveness of antiplatelet therapy with Clopidogrelum. That is ensured by determining laboratory blood counts – hematocrit, hemoglobin, lipid plasma fractions and total cholesterol, high-density lipoprotein content, prothrombin index, international normalized ratio. Also, the level of neurological deficiency is assessed by the National Institute of Health Stroke Assessment Scale and the degree of main arterial involvement by the ultrasound Doppler sonography findings. Method includes determining gradations and numerical values of laboratory and clinical values, afterwards calculating prognostic coefficients F₁ and F₂ by formulas. If F₁ is more than F₂, a probability of high efficacy of the antiaggregant therapy with Clopidogrelum in ischemic stroke is predicted, and if F₁ is less than F₂, the probability of low efficacy is predicted.;EFFECT: invention provides the possibility of determining the laboratory effectiveness of the preparation Clopidogrelum until it is prescribed for treatment, as well as for secondary prevention of the patient with ischemic stroke.;1 cl, 4 tbl, 2 ex