METHOD FOR PREDICTION OF DEVELOPING NEURODEGENERATIVE DISEASES, UNDERLYING THE PATHOGENESIS OF WHICH IS GAMMA-SYNUCLEINOPATHY

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to neurology and ophthalmology, and can be used for prediction of development of neurodegenerative diseases in mice, in the basis of pathogenesis of which lies γ-synucleinopathy. An intraocular pressure (IOP) is determined before and after the instillation in the conjunctival cavity of melatonin 0.1 %, or haloperidol 0.2 %, or dopamine 10 %. If the IOP decreases more than 4 mm Hg for more than 1 hour, developing neurodegenerative diseases are predicted along γ-synucleinopathy.;EFFECT: method provides formation of risk groups of developing neurodegenerative diseases and determination of possible tactics of preventive measures due to definition of IOP in mice before and after single instillation of one of regulators of dopaminergic system: dopamine, haloperidol, melatonin.;1 cl, 3 dwg, 3 ex