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HIGH DOSAGE STRENGTH TABLETS OF RUCAPARIB
HIGH DOSAGE STRENGTH TABLETS OF RUCAPARIB
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机译:rucaparib高剂量强度片剂
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摘要
FIELD: medicine; pharmaceuticals.;SUBSTANCE: invention refers to pharmaceutics, particularly to a tablet for treating diseases mediated by the activity of poly(ADP-ribose)polymerase. As an active ingredient, tablets contain 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one is in concentration of 45–90 % wt./wt. Invention discloses a composition obtained by dry granulation, as well as capsule containing 45–90 % wt./wt. of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one.;EFFECT: invention implementation consists in creation of tablets with increased dosage of rucaparib.;28 cl, 13 dwg, 10 tbl, 6 ex
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