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Macroporous, biodegradable organically cross-linked silicate hybrid material for implantation, process for its preparation and its use

机译:用于植入的大孔,可生物降解的有机交联硅酸盐杂化材料,其制备方法及其用途

摘要

Biodegradable silicate hybrid material containing a) silsesquioxanes and b) an organic multi-armed linker, characterized in that the organic multi-arm linker at least one of the compound I of the general structure with R = alkyl, x from 1 to 5, y from 0 to 30, Rz selected from -CH 2 -, -CH (CH 3 ) -, -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 - and -CH 2 -O-CH 2 -CH 2 -, z from 1 to 15, L selected from -C (= O) -NH-CH 2 -CH 2 -CH 2 -, -CH 2 -CH (OH) -CH 2 -O-CH 2 -CH 2 -CH 2 -, - CH (CH 2 OH) -CH 2 -O-CH 2 -CH 2 -CH 2 -, -CH 2 -CH 2 -CH 2 -, -C (= O) -CH 2 -NH-CH 2 -CH 2 -CH 2 - and - C (= O) -CH 2 -CH 2 -C (= O) -NH-CH 2 -CH 2 -CH 2 -, and R 1 = alkyl, and or the compound II of the general structure C (R 2 ) 4 with R 2 is the same with x from 1 to 5, y 'from 0 to 20, z from 1 to 15, Rz selected from -CH 2 -, -CH (CH 3 ) -, -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 - and -CH 2 -O-CH 2 -CH 2 -, L selected from -C (= O) -NH-CH 2 -CH 2 -CH 2 -, -CH 2 -CH (OH) -CH 2 -O-CH 2 -CH 2 -CH 2 -, - CH (CH 2 OH) -CH 2 -O-CH 2 -CH 2 -CH 2 -, -CH 2 -CH 2 -CH 2 -, -C (= O) -CH 2 -NH-CH 2 -CH 2 -CH 2 - and - C (= O) -CH 2 -CH 2 -C (= O) -NH-CH 2 -CH 2 -CH 2 -, and R 1 = alkyl, and covalently bound to the silsesquioxanes.
机译:包含a)倍半硅氧烷和b)有机多臂连接基的可生物降解的硅酸盐杂化材料,其特征在于,该有机多臂连接基中的至少一种通式I的化合物I具有以下化学组成: R =烷基,x从1到5,y从0到30,Rz选自-CH 2 -,-CH(CH 3 )-,-CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -和-CH 2 -O-CH 2 -CH 2 -,z从1到15,从-C(= O)-NH-中选择L CH 2 -CH 2 -CH 2 -,-CH 2 -CH(OH)-CH 2 -O-CH 2 -CH 2 -CH 2 -,-CH(CH 2 OH)-CH 2 -O-CH 2 -CH 2 -CH 2 -,-CH 2 -CH 2 -CH 2 -,-C(= O)-CH 2 -NH-CH 2 -CH 2 -CH 2 -和-C(= O)-CH 2 -CH 2 -C(= O)-NH-CH 2 -CH 2 -CH 2 -,并且R 1 =烷基,或通式II的化合物具有R 2的C(R 2 4 是与相同的 />,x从1到5 ,y'从0到20,z从1到15,Rz选自-CH 2 -,-CH(CH 3 )-,-CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -和-CH 2 -O-CH 2 -CH 2 -,从-C(= O)-NH-CH 2 -CH 2 -CH 2 -,-CH 2 -CH(OH)-CH 2 -O -CH 2 -CH 2 -CH 2 -,-CH(CH 2 OH)-CH 2 -O-CH 2 -CH 2 -CH 2 -,-CH 2 -CH 2 -CH 2 -,-C(= O)-CH 2 -NH-CH 2 -CH 2 -CH 2 -和-C(= O)-CH 2 -CH 2 -C (= O)-NH-CH 2 -CH 2 -CH 2 < / Sub>-和R 1 =烷基,并与硅倍半氧烷共价键合。

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