首页>
外国专利>
HUMAN SOURCE EGF STRUCTURAL DOMAIN PROTEIN AND APPLICATION OF SAME
HUMAN SOURCE EGF STRUCTURAL DOMAIN PROTEIN AND APPLICATION OF SAME
展开▼
机译:人源EGF结构域蛋白及其应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
In the invention, the minimum inhibitory concentrations of human-originatcd EGF domain proteins against different Gram-negative bacteria are detected with the in vitro antibacterial activity. It has been shown that the human-originated EGF domain proteins have an obvious inhibitory effect on the Gram-negative bacteria, so as to develop a novel class of medicaments for treating Gram-negative bacteria infection. It has been demonstrated by silver staining that the human-originated EGF domain proteins have the effect on hydrolyzing and eliminating the endotoxin, which facilitates the development of a novel class of medicaments for treating endotoxemia. The amino acid sequences of the human-originated EGF domain proteins are the one described in SEQ ID NO: 1 in the sequence listing, or those having homology of over 50% to the amino acid sequence described in SEQ ID NO: 1.
展开▼
机译:在本发明中,通过体外抗菌活性检测了人源EGF结构域蛋白对不同革兰氏阴性细菌的最小抑制浓度。研究表明,人源EGF结构域蛋白对革兰氏阴性菌具有明显的抑制作用,从而开发出一类新型的革兰氏阴性菌感染治疗药物。银染已证明,人类起源的EGF结构域蛋白具有水解和消除内毒素的作用,这促进了用于治疗内毒素血症的新型药物的开发。人源EGF结构域蛋白的氨基酸序列是序列表中SEQ ID NO:1中描述的氨基酸序列,或与SEQ ID NO:1中描述的氨基酸序列具有超过50%同源性的那些。
展开▼