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STERIC-HINDRANCE HYBRIDIZATION SYSTEMS, ASSAYS AND METHODS ASSOCIATED THERETO
STERIC-HINDRANCE HYBRIDIZATION SYSTEMS, ASSAYS AND METHODS ASSOCIATED THERETO
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机译:位阻混合系统,相关测定和方法
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摘要
The present disclosure provides target detection and quantification systems as well as related methods based on the use of steric hindrance (either created by the target itself or a macromolecular entity used to bind to the target) to prevent or limit the hybridizing between an anchoring oligonucleotide (associated to a substrate) and a signaling oligonucleotide or a combination of signaling oligonucleotides (capable of specifically binding the target or the macromolecular entity).
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