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BIOMARKERS FOR COGNITIVE DYSFUNCTION DISEASES AND METHOD FOR DETECTING COGNITIVE DYSFUNCTION DISEASE USING BIOMARKERS
BIOMARKERS FOR COGNITIVE DYSFUNCTION DISEASES AND METHOD FOR DETECTING COGNITIVE DYSFUNCTION DISEASE USING BIOMARKERS
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机译:认知功能障碍疾病的生物标志物和利用生物标志物检测认知功能障碍疾病的方法
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摘要
Biomarkers for detecting cognitive dysfunction diseases and methods for detecting cognitive dysfunction diseases using the biomarkers are provided. A method for detecting cognitive dysfunction diseases comprising measuring one or more biomarkers for detecting cognitive dysfunction diseases selected from the following (a), (b), and (c) in a biological sample simultaneously or separately: (a) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of apolipoprotein A1 comprising the amino acid sequence represented by SEQ ID NO:1 or a partial peptide thereof; (b) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of transthyretin comprising the amino acid sequence represented by SEQ ID NO:2 or a partial peptide thereof; and (c) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of complement C3 comprising the amino acid sequence represented by SEQ ID NO:3 or a partial peptide thereof.
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机译:本发明提供了用于检测认知功能障碍疾病的生物标记物以及使用该生物标记物检测认知功能障碍疾病的方法。一种检测认知功能障碍疾病的方法,包括同时或分别测量一种或多种生物样品中选自以下(a),(b)和(c)的用于检测认知功能障碍疾病的生物标记物:(a)用于检测认知能力的生物标记物由包含由SEQ ID NO:1表示的氨基酸序列的载脂蛋白A1的完整蛋白或其部分肽组成的功能障碍性疾病; (b)一种用于检测认知功能障碍疾病的生物标志物,其由完整的运甲状腺素蛋白构成,其包含SEQ ID NO:2所示的氨基酸序列或其部分肽; (c)一种用于检测认知功能障碍疾病的生物标志物,其由补体C3的完整蛋白组成,所述完整蛋白包含SEQ ID NO:3所示的氨基酸序列或其部分肽。
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