SABRE NMR ANALYSIS METHOD

摘要

The invention provides a method for the detection with SABRE magnetic resonance of an analyte at an unknown concentration Csub in a complex sample, the method comprising: (a) providing a series of mixtures M1, M2, …, Mn, wherein each mixture comprises a predefined part of the complex sample comprising the analyte, a SABRE catalyst at a concentration Cm, and especially also a co-substrate at a concentration Cco-sub, wherein CsubCmCco-sub; and wherein two or more of the mixtures are provided with a known concentration of added analyte for standard addition determination of the unknown concentration of said analyte; and (b) applying p-H2 (para H2) to the mixtures and measuring with nuclear magnetic resonance the magnetic resonance response of the mixtures; and determining from the magnetic resonance response of the series of mixtures the unknown concentration of the analyte.