METHOD FOR DIAGNOSING PROSTATIC DISEASE VIA BACTERIAL METAGENOMIC ANALYSIS

摘要

The present invention relates to a method of diagnosing prostatic diseases such as prostate cancer, prostatic hyperplasia, and the like through bacterial metagenomic analysis, and more particularly, to a method of diagnosing prostate cancer or prostatic hyperplasia by analyzing an increase or decrease in content of extracellular vesicles derived from specific bacteria through bacterial metagenomic analysis using a subject-derived sample. An extracellular vesicle secreted from a bacterium present in the environment can be absorbed into the body and directly affect the occurrence of inflammation and cancer, and prostatic diseases such as prostate cancer, prostatic hyperplasia, and the like is difficult to diagnose early on before any symptom appears, which makes efficient treatment difficult. As such, through the metagenomic analysis on a gene present in a bacterium-derived extracellular vesicle using a human body-derived sample according to the present invention, the risk of the onset of prostate cancer and prostatic hyperplasia can be predicted in advance, enabling early diagnosis and prediction of a prostatic disease risk group and delay of the time of the onset or prevention of the onset with proper care, and early diagnosis is still possible even after the onset, which can lower the incidence rate of prostatic disease and enhance the treatment effect.