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METHOD FOR SELECTING INDIVIDUALS TO BE ADMINISTERED IMMUNE CHECKPOINT INHIBITOR

机译:选择要管理的免疫检查点抑制剂的个人的方法

摘要

(Problem to be Solved) An object is to provide a method for selecting individuals for whom administration of an immune checkpoint inhibitor will be effective by collecting tumor tissue from individuals suffering from tumors and determining the expression levels of B7-H3 in the collected tumor tissue. (Solution) A method for selecting an individual to be a candidate for administration of an immune checkpoint inhibitor in treatment of a tumor, comprising: (1) a step of collecting a tumor tissue from the individual, (2) a step of determining the extent of B7-H3 expression in the tumor tissue collected in step (1), and (3) a step of selecting the individual as an individual to be a candidate for administration of the immune checkpoint inhibitor if the B7-H3 expression level is considered to be negative, is provided.
机译:(要解决的问题)目的是提供一种方法,该方法通过从患有肿瘤的个体中收集肿瘤组织并确定所收集的肿瘤组织中B7-H3的表达水平来选择对其施用免疫检查点抑制剂有效的个体。 。 (解决方案)一种选择个体作为治疗肿瘤的免疫检查点抑制剂的候选药物的方法,包括:(1)从该个体收集肿瘤组织的步骤,(2)确定所述个体的方法。步骤(1)和(3)收集的肿瘤组织中B7-H3表达的程度,如果考虑到B7-H3表达水平,则选择该个体作为免疫检查点抑制剂的候选药物被否定。

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