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Imaging mass analysis data processing method and imaging mass spectrometer

机译:成像质量分析数据处理方法及成像质谱仪

摘要

In the case where the spatial measurement point intervals in imaging mass analysis data of two samples to be compared are different and where the degrees of spatial distribution spreading of substances are compared, one of the data is defined as a reference, the measurement point intervals in the other of the data are redefined so as to be equalized to the reference, and a mass spectrum at each virtual measurement point set as a result of the redefinition is obtained through interpolation or extrapolation based on a mass spectrum at an actual measurement points (S7). In the case where the arrays of the m/z values of mass spectra are different for each sample, the m/z value positions of the mass spectrum in one of the data are defined as a reference, and the intensity values corresponding to the reference m/z values are obtained through interpolation or extrapolation for the mass spectrum of the other of the data (S8). Because the measurement point intervals and the arrays of the m/z values are equalized in this way, the imaging mass analysis data can be combined with each other so as to be treated as one piece of data, whereby processing such as the creation of a peak matrix for a statistical analysis can be simply performed. Accordingly, a statistical analysis for comparing imaging mass analysis data respectively obtained from a plurality of samples can be simply performed, and the accuracy of the statistical analysis can be improved.
机译:在要比较的两个样本的成像质量分析数据中的空间测量点间隔不同并且比较物质的空间分布扩展程度的情况下,将数据之一定义为参考,将测量点间隔定义为重新定义另一个数据以使其等于参考值,并根据实际测量点处的质谱值通过内插或外推获得作为重新定义结果而设置的每个虚拟测量点处的质谱图(S7 )。在每个样品的质谱m / z值阵列不同的情况下,将其中一个数据中质谱的m / z值位置定义为参考,并且强度值对应于该参考通过对另一个数据的质谱进行内插或外推获得m / z值(S8)。由于以这种方式使测量点间隔和m / z值的数组相等,因此可以将成像质量分析数据彼此组合,以将其视为一条数据,从而进行诸如可以轻松执行用于统计分析的峰矩阵。因此,可以简单地执行用于比较分别从多个样本获得的成像质量分析数据的统计分析,并且可以提高统计分析的准确性。

著录项

  • 公开/公告号EP2797104B1

    专利类型

  • 公开/公告日2019-11-20

    原文格式PDF

  • 申请/专利权人 SHIMADZU CORPORATION;

    申请/专利号EP20140165384

  • 发明设计人 IKEGAMI MASAHIRO;KAJIHARA SHIGEKI;

    申请日2014-04-22

  • 分类号H01J49;

  • 国家 EP

  • 入库时间 2022-08-21 11:41:16

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