ASSESSMENT OF NOTCH CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION

摘要

The present invention relates to a computer-implemented method for inferring activity of a Notch cellular signaling pathway in a subject based on expression levels of three or more target genes of the Notch cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a Notch cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the Notch cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a Notch cellular signaling pathway in a subject, and to the use of such kits in performing the method.