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CARRIER FOR NEGATIVELY CHARGED DRUGS COMPRISING A CATIONIC LIPID AND A PREPARATION METHOD THEREOF

机译：包含阳离子脂质的带负电荷的药物载体及其制备方法

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摘要

Disclosed are a carrier for delivering a negatively charged drug, comprising a cationic lipid represented by formula 1, and a preparation method thereof. Also disclosed is a pharmaceutical composition comprising a negatively charged drug and a cationic lipid represented by formula 1, wherein the negatively charged drug forms a complex with the cationic lipid. The composition can increase the in vivo stability of the negatively charged drug after local or systemic administration and allows the intracellular delivery of the negatively charged drug. Thus, the composition will be useful for improving the therapeutic effect of the negatively charged drug.

机译：公开了一种用于输送带负电荷的药物的载体，其包含由式1表示的阳离子脂质及其制备方法。还公开了一种药物组合物，其包含带负电荷的药物和由式1表示的阳离子脂质，其中所述带负电荷的药物与阳离子脂质形成复合物。该组合物可以在局部或全身给药后增加带负电荷的药物的体内稳定性，并允许带负电荷的药物在细胞内递送。因此，该组合物将用于改善带负电荷的药物的治疗效果。 展开▼

著录项

公开/公告号EP3695850A1

专利类型

公开/公告日2020-08-19

原文格式PDF

申请/专利权人 SAMYANG BIOPHARMACEUTICALS CORPORATION;
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申请/专利号EP20200157580

发明设计人 CHOI SUNG-WON;LA MUHN-HO;SON JI-YEON;SEO MIN-HYO;
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申请日2011-12-30

分类号A61K47/18;A61K47/08;A61K31/175;A61K9/127;

国家 EP

入库时间 2022-08-21 11:40:32

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2. 包含阳离子脂质的用于带负电荷的药物的载体及其制备方法 [P] . 中国专利： CN103476431A . 2013-12-25

3. CARRIER FOR NEGATIVELY CHARGED DRUGS COMPRISING A CATIONIC LIPID AND A PREPARATION METHOD THEREOF [P] . IN2013CN04444A . 2016-06-10

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