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A FULLY-HUMAN T CELL RECEPTOR SPECIFIC FOR THE 369-377 EPITOPE DERIVED FROM THE HER2/NEU (ERBB2) RECEPTOR PROTEIN
A FULLY-HUMAN T CELL RECEPTOR SPECIFIC FOR THE 369-377 EPITOPE DERIVED FROM THE HER2/NEU (ERBB2) RECEPTOR PROTEIN
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机译:特异于HER2 / NEU(ERBB2)受体蛋白369-377表位的全人类T细胞受体
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摘要
The present invention relates to compositions and methods for treating HER2/Neu (ERBB2) expressing cancer cells. In some embodiments, the invention includes an isolated T cell receptor (TCR) having high affinity for and that specifically binds ERBB2369-377 epitope on a target cell. Other embodiments include a T cell or a population of T cells modified to express ERBB2-specific TCR. Further embodiments include methods of using ERBB2-specific TCR gene transfer for treating ERBB2 expressing cancer cells. Also included are methods and pharmaceutical compositions comprising the modified T cells for adoptive therapy.
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