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METHODS FOR TREATMENT OF ALPORT SYNDROME
METHODS FOR TREATMENT OF ALPORT SYNDROME
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机译:高度综合症的治疗方法
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摘要
Provided herein are methods for the treatment of Alport Syndrome, using modified oligonucleotides targeted to miR-21. In certain embodiments, a modified oligonucleotide targeted to miR-21 improves kidney function and/or reduces fibrosis in subjects having Alport Syndrome. In certain embodiments, administration of a modified oligonucleotide targeted to miR-21 delays the onset of end-stage renal disease in a subject having Alport Syndrome. In certain embodimentsm a modified oligonucleotide targetd to miR-21 delays the need for dialysis or kidney transplant in a subject having Alport Syndrome.
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