COMPOUND FOR THE PREVENTION OR TREATMENT OF PRE-ECLAMPSIA

摘要

The present invention provides a compound for the sequestration of anti-Epstein-Barr virus nuclear antigen 1 (EBNA-1) antibodies and/or anti human melatonin-related receptor (GPR50) antibodies present in a human individual, the compound comprising a biopolymer scaffold and at least two peptides with a sequence length of 7-13 amino acids, wherein each of the peptides independently comprises a 7-13 amino-acid sequence fragment of the EBNA1 sequence identified by UniProt accession code Q1HVF7 or P03211 or of the GPR50 sequence identified by UniProt accession code Q13585, wherein the peptides are covalently bound to the biopolymer scaffold, wherein the biopolymer scaffold is selected from the group consisting of human globulins, preferably from the group consisting of human immunoglobulins and human haptoglobin, and human albumin. This compound is useful in the prevention or treatment of pre-eclampsia.