AHR SIGNATURE MARKER SET

摘要

The present invention relates to the generation and uses of an improved set of genetic markers that are aryl hydrocarbon receptor (AHR) target genes, designated as "AHR signature". This new signature allows to efficiently determine AHR activation subgroups, for example for an improved classification of tumors. The signature comprises markers that are important in diagnosis and therapy, for example for selecting patients for treatment with AHR activation modulating interventions, and monitoring of therapy response.