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IDENTIFICATION OF CYCLIC PEPTIDE AGONISTS OF GALANIN RECEPTOR 2 AND 3 GUIDED BY SPEXIN SOLUTION STRUCTURE
IDENTIFICATION OF CYCLIC PEPTIDE AGONISTS OF GALANIN RECEPTOR 2 AND 3 GUIDED BY SPEXIN SOLUTION STRUCTURE
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机译:鞘脂溶液结构指导的甘丙肽受体2和3的环肽激动剂的鉴定
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摘要
Cyclic peptide agonists toward human galanin receptor 2 (GalR2) and galanin receptor 3 (GalR3) based on hidden conformation of spexin solution structure for GalR2 and GalR3-related and spexin-deficient disorders are designed and synthesized. LH101, LH102, and LH101 (Ac) are potent spexin analogs with prolonged action, which can be used in the treatment of GalR2 and GalR3-related diseases and spexin-deficient disorders, such as obesity.
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